hCTLA4‐Ig transgene expression in keratocytes modulates rejection of corneal xenografts in a pig to non‐human primate anterior lamellar keratoplasty model
Identifieur interne : 000003 ( Istex/Checkpoint ); précédent : 000002; suivant : 000004hCTLA4‐Ig transgene expression in keratocytes modulates rejection of corneal xenografts in a pig to non‐human primate anterior lamellar keratoplasty model
Auteurs : Bertrand Vabres [France] ; Stéphanie Le Bas-Bernardet [France] ; David Riochet [France] ; Yan Chérel [France] ; David Minault [France] ; Jérémy Hervouet [France] ; Yvette Ducournau [France] ; Anne Moreau [France] ; Véronique Daguin [France] ; Flora Coulon [France] ; Annaïck Pallier [France] ; Sophie Brouard [France] ; Simon C. Robson [États-Unis] ; Mark B. Nottle [Australie] ; Peter J. Cowan [Australie] ; Eric Venturi [France] ; Pascal Mermillod [France] ; Philippe Brachet [France] ; Cesare Galli [Italie] ; Irina Lagutina [Italie] ; Roberto Duchi [Italie] ; Jean-Marie Bach [France] ; Gilles Blancho [France] ; Jean-Paul Soulillou [France] ; Bernard Vanhove [France]Source :
- Xenotransplantation [ 0908-665X ] ; 2014-09.
Abstract
Human corneal allografting is an established procedure to cure corneal blindness. However, a shortage of human donor corneas as well as compounding economic, cultural, and organizational reasons in many countries limit its widespread use. Artificial corneas as well as porcine corneal xenografts have been considered as possible alternatives. To date, all preclinical studies using de‐cellularized pig corneas have shown encouraging graft survival results; however, relatively few studies have been conducted in pig to non‐human primate (NHP) models, and particularly using genetically engineered donors.
Url:
DOI: 10.1111/xen.12107
Affiliations:
- Australie, France, Italie, États-Unis
- Massachusetts, Pays de la Loire, Victoria (État), Émilie-Romagne
- Bologne, Boston, Melbourne, Nantes
- Université de Bologne, Université de Melbourne, Université de Nantes
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Links to Exploration step
ISTEX:D05B430488A4A0779AFBB6720BE860C48C21A21DLe document en format XML
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type="city">Nantes</settlement></placeName><orgName type="university">Université de Nantes</orgName></affiliation></author><author><name sortKey="Pallier, Annaick" sort="Pallier, Annaick" uniqKey="Pallier A" first="Annaïck" last="Pallier">Annaïck Pallier</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé Et de la Recherche Médicale Unité Mixte de Recherche 1064, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">France</country><wicri:regionArea>Institut de Transplantation Urologie Néphrologie, Université de Nantes, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement><settlement type="city">Nantes</settlement></placeName><orgName type="university">Université de Nantes</orgName></affiliation></author><author><name sortKey="Brouard, Sophie" sort="Brouard, Sophie" uniqKey="Brouard S" first="Sophie" last="Brouard">Sophie Brouard</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé Et de la Recherche Médicale Unité Mixte de Recherche 1064, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">France</country><wicri:regionArea>Institut de Transplantation Urologie Néphrologie, Université de Nantes, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement><settlement type="city">Nantes</settlement></placeName><orgName type="university">Université de Nantes</orgName></affiliation></author><author><name sortKey="Robson, Simon C" sort="Robson, Simon C" uniqKey="Robson S" first="Simon C." last="Robson">Simon C. Robson</name><affiliation wicri:level="3"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Transplant Center, Beth Israel Deaconess Medical Center/Harvard Medical School, MA, Boston</wicri:regionArea><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Nottle, Mark B" sort="Nottle, Mark B" uniqKey="Nottle M" first="Mark B." last="Nottle">Mark B. Nottle</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Obstetrics and Gynecology, University of Adelaide, SA, Adelaide</wicri:regionArea><wicri:noRegion>Adelaide</wicri:noRegion></affiliation></author><author><name sortKey="Cowan, Peter J" sort="Cowan, Peter J" uniqKey="Cowan P" first="Peter J." last="Cowan">Peter J. Cowan</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Immunology Research Center, St Vincent's Hospital, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medicine, University of Melbourne, Victoria, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region><settlement type="city">Melbourne</settlement></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Venturi, Eric" sort="Venturi, Eric" uniqKey="Venturi E" first="Eric" last="Venturi">Eric Venturi</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>INRA, UR85 Physiologie de la Reproduction et des Comportements, Nouzilly</wicri:regionArea><wicri:noRegion>Nouzilly</wicri:noRegion><wicri:noRegion>Nouzilly</wicri:noRegion></affiliation></author><author><name sortKey="Mermillod, Pascal" sort="Mermillod, Pascal" uniqKey="Mermillod P" first="Pascal" last="Mermillod">Pascal Mermillod</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>INRA, UR85 Physiologie de la Reproduction et des Comportements, Nouzilly</wicri:regionArea><wicri:noRegion>Nouzilly</wicri:noRegion><wicri:noRegion>Nouzilly</wicri:noRegion></affiliation></author><author><name sortKey="Brachet, Philippe" sort="Brachet, Philippe" uniqKey="Brachet P" first="Philippe" last="Brachet">Philippe Brachet</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé Et de la Recherche Médicale Unité Mixte de Recherche 1064, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la 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Scienze Mediche Veterinarie, Università di Bologna, Ozzano Emilia</wicri:regionArea><orgName type="university">Université de Bologne</orgName><placeName><settlement type="city">Bologne</settlement><region nuts="2" type="region">Émilie-Romagne</region></placeName></affiliation></author><author><name sortKey="Lagutina, Irina" sort="Lagutina, Irina" uniqKey="Lagutina I" first="Irina" last="Lagutina">Irina Lagutina</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Laboratorio di Tecnologie della Riproduzione, Avantea, Cremona</wicri:regionArea><wicri:noRegion>Cremona</wicri:noRegion></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Scienze Mediche Veterinarie, Università di Bologna, Ozzano Emilia</wicri:regionArea><orgName type="university">Université de Bologne</orgName><placeName><settlement type="city">Bologne</settlement><region nuts="2" type="region">Émilie-Romagne</region></placeName></affiliation></author><author><name sortKey="Duchi, Roberto" sort="Duchi, Roberto" uniqKey="Duchi R" first="Roberto" last="Duchi">Roberto Duchi</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Laboratorio di Tecnologie della Riproduzione, Avantea, Cremona</wicri:regionArea><wicri:noRegion>Cremona</wicri:noRegion></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Scienze Mediche Veterinarie, Università di Bologna, Ozzano Emilia</wicri:regionArea><orgName type="university">Université de Bologne</orgName><placeName><settlement type="city">Bologne</settlement><region nuts="2" type="region">Émilie-Romagne</region></placeName></affiliation></author><author><name sortKey="Bach, Jean Arie" sort="Bach, Jean Arie" uniqKey="Bach J" first="Jean-Marie" last="Bach">Jean-Marie Bach</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>ONIRIS, EA4644, IECM, Institut National de la Recherche Agronomique, Université Bretagne Loire, USC1383, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Blancho, Gilles" sort="Blancho, Gilles" uniqKey="Blancho G" first="Gilles" last="Blancho">Gilles Blancho</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier, Universitaire de Nantes, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé Et de la Recherche Médicale Unité Mixte de Recherche 1064, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">France</country><wicri:regionArea>Institut de Transplantation Urologie Néphrologie, Université de Nantes, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement><settlement type="city">Nantes</settlement></placeName><orgName type="university">Université de Nantes</orgName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">France</country></affiliation></author><author><name sortKey="Soulillou, Jean Aul" sort="Soulillou, Jean Aul" uniqKey="Soulillou J" first="Jean-Paul" last="Soulillou">Jean-Paul Soulillou</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé Et de la Recherche Médicale Unité Mixte de Recherche 1064, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">France</country><wicri:regionArea>Institut de Transplantation Urologie Néphrologie, Université de Nantes, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement><settlement type="city">Nantes</settlement></placeName><orgName type="university">Université de Nantes</orgName></affiliation></author><author><name sortKey="Vanhove, Bernard" sort="Vanhove, Bernard" uniqKey="Vanhove B" first="Bernard" last="Vanhove">Bernard Vanhove</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier, Universitaire de Nantes, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé Et de la Recherche Médicale Unité Mixte de Recherche 1064, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">France</country><wicri:regionArea>Institut de Transplantation Urologie Néphrologie, Université de Nantes, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement><settlement type="city">Nantes</settlement></placeName><orgName type="university">Université de Nantes</orgName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Xenotransplantation</title><title level="j" type="alt">XENOTRANSPLANTATION</title><idno type="ISSN">0908-665X</idno><idno type="eISSN">1399-3089</idno><imprint><biblScope unit="vol">21</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="431">431</biblScope><biblScope unit="page" to="443">443</biblScope><biblScope unit="page-count">13</biblScope><date type="published" when="2014-09">2014-09</date></imprint><idno type="ISSN">0908-665X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0908-665X</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Human corneal allografting is an established procedure to cure corneal blindness. However, a shortage of human donor corneas as well as compounding economic, cultural, and organizational reasons in many countries limit its widespread use. Artificial corneas as well as porcine corneal xenografts have been considered as possible alternatives. To date, all preclinical studies using de‐cellularized pig corneas have shown encouraging graft survival results; however, relatively few studies have been conducted in pig to non‐human primate (NHP) models, and particularly using genetically engineered donors.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>Italie</li><li>États-Unis</li></country><region><li>Massachusetts</li><li>Pays de la Loire</li><li>Victoria (État)</li><li>Émilie-Romagne</li></region><settlement><li>Bologne</li><li>Boston</li><li>Melbourne</li><li>Nantes</li></settlement><orgName><li>Université de Bologne</li><li>Université de Melbourne</li><li>Université de Nantes</li></orgName></list><tree><country name="France"><region name="Pays de la Loire"><name sortKey="Vabres, Bertrand" sort="Vabres, Bertrand" uniqKey="Vabres B" first="Bertrand" last="Vabres">Bertrand Vabres</name></region><name sortKey="Bach, Jean Arie" sort="Bach, Jean Arie" uniqKey="Bach J" first="Jean-Marie" last="Bach">Jean-Marie Bach</name><name sortKey="Blancho, Gilles" sort="Blancho, Gilles" uniqKey="Blancho G" first="Gilles" last="Blancho">Gilles Blancho</name><name sortKey="Blancho, Gilles" sort="Blancho, Gilles" uniqKey="Blancho G" first="Gilles" last="Blancho">Gilles Blancho</name><name sortKey="Blancho, Gilles" sort="Blancho, Gilles" uniqKey="Blancho G" first="Gilles" last="Blancho">Gilles Blancho</name><name sortKey="Blancho, Gilles" sort="Blancho, Gilles" uniqKey="Blancho G" first="Gilles" last="Blancho">Gilles Blancho</name><name sortKey="Brachet, Philippe" sort="Brachet, Philippe" uniqKey="Brachet P" first="Philippe" last="Brachet">Philippe Brachet</name><name sortKey="Brachet, Philippe" sort="Brachet, Philippe" uniqKey="Brachet P" first="Philippe" last="Brachet">Philippe Brachet</name><name sortKey="Brouard, Sophie" sort="Brouard, Sophie" uniqKey="Brouard S" first="Sophie" last="Brouard">Sophie Brouard</name><name sortKey="Brouard, Sophie" sort="Brouard, Sophie" uniqKey="Brouard S" first="Sophie" last="Brouard">Sophie Brouard</name><name sortKey="Cherel, Yan" sort="Cherel, Yan" uniqKey="Cherel Y" first="Yan" last="Chérel">Yan Chérel</name><name sortKey="Coulon, Flora" sort="Coulon, Flora" uniqKey="Coulon F" first="Flora" last="Coulon">Flora Coulon</name><name sortKey="Coulon, Flora" sort="Coulon, Flora" uniqKey="Coulon F" first="Flora" last="Coulon">Flora Coulon</name><name sortKey="Daguin, Veronique" sort="Daguin, Veronique" uniqKey="Daguin V" first="Véronique" last="Daguin">Véronique Daguin</name><name sortKey="Daguin, Veronique" sort="Daguin, Veronique" uniqKey="Daguin V" first="Véronique" last="Daguin">Véronique Daguin</name><name sortKey="Ducournau, Yvette" sort="Ducournau, Yvette" uniqKey="Ducournau Y" first="Yvette" last="Ducournau">Yvette Ducournau</name><name sortKey="Hervouet, Jeremy" sort="Hervouet, Jeremy" uniqKey="Hervouet J" first="Jérémy" last="Hervouet">Jérémy Hervouet</name><name sortKey="Hervouet, Jeremy" sort="Hervouet, Jeremy" uniqKey="Hervouet J" first="Jérémy" last="Hervouet">Jérémy Hervouet</name><name sortKey="Le Bas Ernardet, Stephanie" sort="Le Bas Ernardet, Stephanie" uniqKey="Le Bas Ernardet S" first="Stéphanie" last="Le Bas-Bernardet">Stéphanie Le Bas-Bernardet</name><name sortKey="Le Bas Ernardet, Stephanie" sort="Le Bas Ernardet, Stephanie" uniqKey="Le Bas Ernardet S" first="Stéphanie" last="Le Bas-Bernardet">Stéphanie Le Bas-Bernardet</name><name sortKey="Le Bas Ernardet, Stephanie" sort="Le Bas Ernardet, Stephanie" uniqKey="Le Bas Ernardet S" first="Stéphanie" last="Le Bas-Bernardet">Stéphanie Le Bas-Bernardet</name><name sortKey="Mermillod, Pascal" sort="Mermillod, Pascal" uniqKey="Mermillod P" first="Pascal" last="Mermillod">Pascal Mermillod</name><name sortKey="Minault, David" sort="Minault, David" uniqKey="Minault D" first="David" last="Minault">David Minault</name><name sortKey="Minault, David" sort="Minault, David" uniqKey="Minault D" first="David" last="Minault">David Minault</name><name sortKey="Moreau, Anne" sort="Moreau, Anne" uniqKey="Moreau A" first="Anne" last="Moreau">Anne Moreau</name><name sortKey="Pallier, Annaick" sort="Pallier, Annaick" uniqKey="Pallier A" first="Annaïck" last="Pallier">Annaïck Pallier</name><name sortKey="Pallier, Annaick" sort="Pallier, Annaick" uniqKey="Pallier A" first="Annaïck" last="Pallier">Annaïck Pallier</name><name sortKey="Riochet, David" sort="Riochet, David" uniqKey="Riochet D" first="David" last="Riochet">David Riochet</name><name sortKey="Riochet, David" sort="Riochet, David" uniqKey="Riochet D" first="David" last="Riochet">David Riochet</name><name sortKey="Riochet, David" sort="Riochet, David" uniqKey="Riochet D" first="David" last="Riochet">David Riochet</name><name sortKey="Soulillou, Jean Aul" sort="Soulillou, Jean Aul" uniqKey="Soulillou J" first="Jean-Paul" last="Soulillou">Jean-Paul Soulillou</name><name sortKey="Soulillou, Jean Aul" sort="Soulillou, Jean Aul" uniqKey="Soulillou J" first="Jean-Paul" last="Soulillou">Jean-Paul Soulillou</name><name sortKey="Vanhove, Bernard" sort="Vanhove, Bernard" uniqKey="Vanhove B" first="Bernard" last="Vanhove">Bernard Vanhove</name><name sortKey="Vanhove, Bernard" sort="Vanhove, Bernard" uniqKey="Vanhove B" first="Bernard" last="Vanhove">Bernard Vanhove</name><name sortKey="Vanhove, Bernard" sort="Vanhove, Bernard" uniqKey="Vanhove B" first="Bernard" last="Vanhove">Bernard Vanhove</name><name sortKey="Venturi, Eric" sort="Venturi, Eric" uniqKey="Venturi E" first="Eric" last="Venturi">Eric Venturi</name></country><country name="États-Unis"><region name="Massachusetts"><name sortKey="Robson, Simon C" sort="Robson, Simon C" uniqKey="Robson S" first="Simon C." last="Robson">Simon C. Robson</name></region></country><country name="Australie"><noRegion><name sortKey="Nottle, Mark B" sort="Nottle, Mark B" uniqKey="Nottle M" first="Mark B." last="Nottle">Mark B. Nottle</name></noRegion><name sortKey="Cowan, Peter J" sort="Cowan, Peter J" uniqKey="Cowan P" first="Peter J." last="Cowan">Peter J. Cowan</name><name sortKey="Cowan, Peter J" sort="Cowan, Peter J" uniqKey="Cowan P" first="Peter J." last="Cowan">Peter J. Cowan</name></country><country name="Italie"><noRegion><name sortKey="Galli, Cesare" sort="Galli, Cesare" uniqKey="Galli C" first="Cesare" last="Galli">Cesare Galli</name></noRegion><name sortKey="Duchi, Roberto" sort="Duchi, Roberto" uniqKey="Duchi R" first="Roberto" last="Duchi">Roberto Duchi</name><name sortKey="Duchi, Roberto" sort="Duchi, Roberto" uniqKey="Duchi R" first="Roberto" last="Duchi">Roberto Duchi</name><name sortKey="Galli, Cesare" sort="Galli, Cesare" uniqKey="Galli C" first="Cesare" last="Galli">Cesare Galli</name><name sortKey="Lagutina, Irina" sort="Lagutina, Irina" uniqKey="Lagutina I" first="Irina" last="Lagutina">Irina Lagutina</name><name sortKey="Lagutina, Irina" sort="Lagutina, Irina" uniqKey="Lagutina I" first="Irina" last="Lagutina">Irina Lagutina</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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